Pre- and Post-transfusion Complement Activation in Transfusion-dependent β-thalassaemia

Liver disease in transfusion dependent thalassaemia major.

AIMS To study the prevalence and severity of liver diseases of transfusion dependent thalassaemia major patients, and correlate the histological and biochemical changes of iron overload in liver with the peripheral blood markers. METHOD Liver biopsy was performed to assess the histological changes and liver iron content (LIC). RESULTS One hundred patients were evaluated (median age 11.7 yea...

Transfusion-dependent thalassaemia: a new era.

1 Royal Australasian College of Surgeons. Surgical Education and Training program. Melbourne: RACS, 2007. http://www.surgeons.org/Content/NavigationMenu/EducationandTraining (accessed Oct 2007). 2 Royal Australasian College of Surgeons. Council highlights August 2007. Melbourne: RACS, 2007. http://www.surgeons.org/Content/NavigationMenu/WhoWeAre/Council/CouncilHighlights/Council_Highlights_Augu...

Endocrine complications in transfusion dependent thalassaemia in Penang Hospital.

Frequent blood transfusions can lead to iron overload which may result in several endocrine complications especially in the absence of adequate chelation therapy. The objectives of this study are to determine the prevalence of endocrine complications in transfusion dependent thalassaemia patients and the correlation of endocrine complications with the degree of iron chelation. This retrospectiv...

When to consider transfusion therapy for patients with non-transfusion-dependent thalassaemia

Non-transfusion-dependent thalassaemia (NTDT) refers to all thalassaemia disease phenotypes that do not require regular blood transfusions for survival. Thalassaemia disorders were traditionally concentrated along the tropical belt stretching from sub-Saharan Africa through the Mediterranean region and the Middle East to South and South-East Asia, but global migration has led to increased incid...

Guidelines for the Management of Non Transfusion Dependent Thalassaemia (ntdt)